Key points

  • We recommend to consult your poison centre with the use of this antidote.
  • It is important to administer pyridoxine without waiting for clinical signs of isoniazid poisoning.
  • Benzodiazepines should be used together with pyridoxine for treating convulsions associated with isoniazid, hydrazine, and gyromitra poisoning; combinig these treatments provides a synergistic effect.
  • In case of a drug shortage, contact your poison centre. Crushed pyridoxine tablets administered via a nasogastric tube may be suggested in some cases. It is also recommended to keep your injectable pyridoxine stock even if it has expired.

© Centre antipoison du Québec, CIUSSS de la Capitale-Nationale, 2017. The information contained in this site may be cited, provided the source is acknowledged. Any use for commercial or advertising purposes is strictly prohibited.

Last updated : 2021-08-31