Key points

  • We recommend to consult your poison centre with the use of this antidote.
  • Efficacy has not been well established. Use only as a last resort after the failure of standard treatment for local anesthetics and cardiovascular toxicity involving liposoluble toxins other than local anesthetics. More literature is available concerning bupivacaine poisoning. 
  • Administration of lipid emulsion and subsequent lipemia can interfere with laboratory measurement of some analytes for several hours and may cause hemodialysis or ECMO circuit occlusion.
  • If ECMO is started, it is recommended to stop the administration of the lipid emulsion.
  • Treatment Algorithms for Cardiovascular Toxicity: 

© Centre antipoison du Québec, CIUSSS de la Capitale-Nationale, 2017. The information contained in this site may be cited, provided the source is acknowledged. Any use for commercial or advertising purposes is strictly prohibited.

Last updated : 2022-11-25