Key points

  • Benztropine (Cogentin™) is an alternative to diphenhydramine in adults for the treatment of extrapyramidal reactions.
  • Extrapyramidal symptoms may recur in the 24 - 48 h following the initial reaction. Diphenhydramine can be administered once again to treat the relapse. Some authors suggest administering diphenhydramine by oral route for prophylaxis for 24 - 48 h to prevent such relapses.

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Last updated : 2022-12-14