Key points

  • We recommend to consult your poison centre with the use of this antidote.
  • Phenobarbital is contraindicated in patients with porphyria, hepatic impairment, and in patients known to be hypersensitive to barbiturates.
  • After IV administration, the onset of action may be delayed for 5 to 15 minutes.
  • In patients presenting with toxin-induced seizures and/or status epilepticus  refractory to benzodiazepines, the administration of IV pyridoxine must be considered after consulting your poison center.  
  • The administration of IV phenytoin does not play a role in the management of toxin-induced seizures and/or toxin-induced status epilepticus.

Last updated : 2024-02-27