Key points

  • We recommend to consult your poison centre with the use of this antidote
  • Consider only as adjunctive therapy for beta blocker intoxication. As first-line therapies, prioritize initiation of IV fluid repletion, vasopressors and high-dose insulin with dextrose. 
  • Considerations that limit the use of glucagon include: time required to prepare IV doses and frequent adverse effects (nausea, vomiting)
  • Higher doses are more likely to achieve maximum hemodynamic response compared with lower doses
  • Treatment Algorithms for Cardiovascular Toxicity:

Last updated : 2022-12-13