Key points  

  • We recommend to consult your poison centre with the use of this antidote
  • In general, N-acetylcysteine (NAC) therapy must be initiated rapidly (less than 8 h) following acute poisoning. 
  • The Rumack-Matthew Nomogram can only be used to evaluate the risk of patients presenting within 24 hours following a single ingestion of acetaminophen. For all other situations, it is strongly advised to consult your poison centre.
  • If any of the following risk factors are present, it is strongly advised to consult your poison centre: isoniazid treatment, alcoholism (without presence of ethanol in the blood), pre-existing liver dysfunction.

© Centre antipoison du Québec, CIUSSS de la Capitale-Nationale, 2019. The information contained in this site may be cited, provided the source is acknowledged. Any use for commercial or advertising purposes is strictly prohibited.

ISSN : 2292-230X

Authors: Bailey B, Blais R, Dubé PA, Friesen M, Gaudreault P, Gosselin S, Laliberté M, Larocque A, St-Onge M

Reviewers: Duval C, Elliott A, Mackenzie C, Murphy N, Letarte A, Pursell R, Thompson M, Yarema M

Last updated: 16-08-2019