Hydroxocobalamin

Key points  

  • We recommend to consult your poison centre with the use of this antidote.
  • Hydroxocobalamin is safe for use in cases of mixed poisoning by cyanide and carbon monoxide.
  • Sodium thiosulfate can be used as an adjuvant if no improvement or only partial improvement after 2 doses of hydroxocobalamin or as an alternative treatment in the event of a severe allergic reaction (e.g., respiratory distress, anaphylaxis) after the first infusion of hydroxocobalamin.
  • Interference with certain blood test results can be observed up to 24-72h after the administration of hydroxocobalamin. Interference with certain urinary analysis results can be observed up to 28 days after the administration.
  • In the section, Special Notes on Administration - Reconstitution, a link to a video describing the reconstitution and the preparation of a 5g vial of hydroxocobalamin for further administraion to an adult patient is available.

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Last updated: 07-06-2018