Dextrose

Key points  

  • We recommend to consult your poison centre with the use of this antidote.
  • Check blood glucose before starting treatment and at regular intervals thereafter.
  • Dextrose requirements are greater with beta blocker poisoning compared to calcium-channel blocker poisoning. The amount of dextrose required to maintain a normal blood glucose level will increase as the hemodynamic status improves. Administration of dextrose for 24 h or more following insulin discontinuation is sometimes required.
  • Given the acceptable maximum osmolarity of solutions for continuous IV infusion via a peripheral line is 850 mOsm/L, the dextrose solution concentration should not exceed 12.5%. A central line (IV or IO) should be inserted as soon as possible.

Last updated: 14-05-2018