Cyproheptadine

Key points  

  • We recommend to consult your poison centre with the use of this antidote.
  • Cyproheptadine is an adjunct to benzodiazepines (please refer to the benzodiazepines monograph).
  • Cyproheptadine is a first generation antihistamine (H1 receptor antagonist) with non-specific serotonin (5-HT2) antagonist activity. It also has anticholinergic properties that should be considered prior to its use.
  • The absorption of the cyproheptadine may be reduced if the patient has received activated charcoal. In such cases, consider using another serotonin antagonist, such a, olanzapine (SL, IM) or risperidone (SL, IM).

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Last updated: 31-05-2018